Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …

Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …

Omic data analysis is steadily growing as a driver of basic and applied molecular biology
research. Core to the interpretation of complex and heterogeneous biological phenotypes …

Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …

A better understanding of the metabolic alterations in immune cells during severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity …

Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …

Malignant brain tumours are the cause of a disproportionate level of morbidity and mortality
among cancer patients, an unfortunate statistic that has remained constant for decades …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …