Polysaccharide production by lactic acid bacteria: from genes to industrial applications

AA Zeidan, VK Poulsen, T Janzen… - FEMS microbiology …, 2017 - academic.oup.com
The ability to produce polysaccharides with diverse biological functions is widespread in
bacteria. In lactic acid bacteria (LAB), production of polysaccharides has long been …

Sepsis: mechanisms of bacterial injury to the patient

H Minasyan - Scandinavian journal of trauma, resuscitation and …, 2019 - Springer
In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …

Sepsis and septic shock: Pathogenesis and treatment perspectives

H Minasyan - Journal of critical care, 2017 - Elsevier
The majority of bacteremias do not develop to sepsis: bacteria are cleared from the
bloodstream. Oxygen released from erythrocytes and humoral immunity kill bacteria in the …

Capsules of Streptococcus pneumoniae and Other Bacteria: Paradigms for Polysaccharide Biosynthesis and Regulation

J Yother - Annual review of microbiology, 2011 - annualreviews.org
Capsular polysaccharides and exopolysaccharides play critical roles in bacterial survival
strategies, and they can have important medical and industrial applications. An immense …

Pivotal roles of the outer membrane polysaccharide export and polysaccharide copolymerase protein families in export of extracellular polysaccharides in gram …

L Cuthbertson, IL Mainprize, JH Naismith… - Microbiology and …, 2009 - journals.asm.org
Many bacteria export extracellular polysaccharides (EPS) and capsular polysaccharides
(CPS). These polymers exhibit remarkably diverse structures and play important roles in the …

Tyrosine phosphorylation: an emerging regulatory device of bacterial physiology

C Grangeasse, AJ Cozzone, J Deutscher… - Trends in biochemical …, 2007 - cell.com
Tyrosine phosphorylation is a key device in numerous cellular functions in eukaryotes, but in
bacteria this protein modification was largely ignored until the mid-1990s. The first …

Bacterial tyrosine kinases: evolution, biological function and structural insights

C Grangeasse, S Nessler… - … Transactions of the …, 2012 - royalsocietypublishing.org
Reversible protein phosphorylation is a major mechanism in the regulation of fundamental
signalling events in all living organisms. Bacteria have been shown to possess a versatile …

Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus

M Rausch, JP Deisinger, H Ulm, A Müller, W Li… - Nature …, 2019 - nature.com
The Gram-positive cell wall consists of peptidoglycan functionalized with anionic
glycopolymers, such as wall teichoic acid and capsular polysaccharide (CP). How the …

Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae

J Nourikyan, M Kjos, C Mercy, C Cluzel, C Morlot… - PLoS …, 2015 - journals.plos.org
Bacterial capsular polysaccharides (CPS) are produced by a multi-protein membrane
complex, in which a particular type of tyrosine-autokinases named BY-kinases, regulate their …

Structural basis for the regulation mechanism of the tyrosine kinase CapB from Staphylococcus aureus

V Olivares-Illana, P Meyer, E Bechet… - PLOS …, 2008 - journals.plos.org
Bacteria were thought to be devoid of tyrosine-phosphorylating enzymes. However, several
tyrosine kinases without similarity to their eukaryotic counterparts have recently been …