Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …

Large datasets describing the quantitative effects of mutations on protein function are
becoming increasingly available. Here, we leverage these datasets to develop Envision …

Aldo-keto reductases (AKRs) are monomeric NAD (P)(H)-dependent oxidoreductases that
play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C …

Many nonsynonymous single nucleotide polymorphisms (nsSNPs) are disease causing due
to effects at protein‐protein interfaces. We have integrated a database of the three …

Abstract Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase
(HSD)/prostaglandin (PG) F 2α synthase) is the only 17β-HSD that is not a short-chain …

The number of reported germline mutations in human nuclear genes, either underlying or
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …

Proteins are Nature's molecular machinery and comprise diverse roles while consisting of
chemically similar building blocks. In recent years, protein engineering and design have …

Aldo-keto reductases (AKRs) are promiscuous NAD (P)(H) dependent oxidoreductases
implicated in the metabolic activation of polycyclic aromatic hydrocarbons (PAH). These …

It is widely accepted that at least 10% of all mutations causing human inherited disease
disrupt splice-site consensus sequences. In contrast to splice-site mutations, the role of …