Organoselenium and organotellurium compounds: toxicology and pharmacology

CW Nogueira, G Zeni, JBT Rocha - Chemical reviews, 2004 - ACS Publications
Organoselenium compounds have found such wide utility because of their effects on an
extraordinary number of very different reactions, including many carbon-carbon bond …

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

CW Nogueira, JBT Rocha - Archives of toxicology, 2011 - Springer
The advance in the area of synthesis and reactivity of organoselenium, as well as the
discovery that selenium was the cause of severe intoxication episodes of livestock in the …

Protective role of aryl and alkyl diselenides on lipid peroxidation

FC Meotti, EC Stangherlin, G Zeni, CW Nogueira… - Environmental …, 2004 - Elsevier
The concept that selenium-containing molecules may be better nucleophiles (and therefore
antioxidants) than classical antioxidants has led to the design of synthetic organoselenium …

Investigations into the potential neurotoxicity induced by diselenides in mice and rats

CW Nogueira, FC Meotti, E Curte, C Pilissao, G Zeni… - Toxicology, 2003 - Elsevier
It is well known that selenium is highly toxic to several species of mammals. Here we report
the potential neurotoxicity of diselenides, as measured by the manifestation of seizures. The …

Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations

JBT Rocha, RA Saraiva, SC Garcia… - Toxicology …, 2012 - academic.oup.com
Abstract δ-ALA-D is a metalloenzyme that has 3 vicinal thiol/thiolate groups that coordinate
with Zn (ii). The proximity between the sulfhydryl groups renders δ-ALA-D extremely …

Oxidative stress in mice is dependent on the free glucose content of the diet

V Folmer, JCM Soares, JBT Rocha - … journal of biochemistry & cell biology, 2002 - Elsevier
In animals, chronic intake of diets with high proportions of rapidly absorbable glucose
promotes the development of insulin resistance. High levels of glucose can produce …

Thiophenes and furans derivatives: a new class of potential pharmacological agents

FC Meotti, DO Silva, ARS Dos Santos, G Zeni… - Environmental …, 2003 - Elsevier
A new class of potential pharmacological thiophenes and furans compounds has been
prepared. The obtained thiophenes and furans derivatives were screened for anti …

Brain and lungs of rats are differently affected by cigarette smoke exposure: antioxidant effect of an organoselenium compound

C Luchese, S Pinton, CW Nogueira - Pharmacological Research, 2009 - Elsevier
Cigarette smoke exposure has been associated with oxidative stress in several organs.
Antioxidant effect of diphenyl diselenide (PhSe) 2, an organoselenium compound, on …

Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds

J Perottoni, OED Rodrigues, MW Paixao, G Zeni… - Food and Chemical …, 2004 - Elsevier
This paper evaluates the ability of organoselenium compounds [ebselen, selenocystine N-
ethyl-carbamate (SeCis), bis-4-isopropyl-2-oxazolinyl phenyl diselenide (AASe)] to prevent …

[HTML][HTML] A high fat diet inhibits δ-aminolevulinate dehydratase and increases lipid peroxidation in mice (Mus musculus)

V Folmer, JCM Soares, D Gabriel, JBT Rocha - The Journal of nutrition, 2003 - Elsevier
The aim of this study was examine the effects of high starch (HS) vs. high fat (HF) feeding on
blood glycated hemoglobin (GHbA 1c) level, thiobarbituric acid-reactive species (TBA-RS) …