Animal embryos need to specify different cell types, and the genetic functions that provide
such controls are easy to comprehend since they result in the formation of overtly …

The existence of males and females is due to two processes: sex determi nation and
differentiation. Sex determination is the process of choosing either the male or the female …

twist and snail are members of the helix-loop-helix and zinc-finger protein families,
respectively, and determine the development of the mesoderm in Drosophila. This paper …

Brachyury (T) mutant embryos are deficient in mesoderm formation and do not complete
axial development. The notochord is most strongly affected. The T gene is expressed …

Homeotic genes encode transcription factors that are thought to specify segmental identity
by regulating expression of subordinate genes. Limb development is repressed in the …

Summary The Polycomb group (PC-G) proteins are responsible for kee** developmental
regulators, like homeotic genes, stably and inheritably repressed during Drosophila …

The leucine-rich repeat structure was first noticed in the primary sequence of leucinerich u2-
glycoprotein (LRG) of human serum (Takahashi et aL, 1985). This protein was so named …

Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder
associated with breast cancer and motor dysfunction, is a neuron-specific nuclear RNA …

A Brief History Long before the discovery of the homeobox (McGinnis et al., 1984; Scott and
Weiner, 1984), Drosophila workers knew that homeotic genes are special. In the late 1940 …

Each abdominal hemisegment in the Drosophila embryo contains a stereotyped array of 30
muscles, each specifically innervated by one or a few motoneurons. We screened 11,000 …