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The path to next-generation disease-modifying immunomodulatory combination therapies in Alzheimer's disease
M Sarazin, J Lagarde, I El Haddad, LC de Souza… - Nature Aging, 2024 - nature.com
The cautious optimism following recent anti-amyloid therapeutic trials for Alzheimer's
disease (AD) provides a glimmer of hope after years of disappointment. Although these …
disease (AD) provides a glimmer of hope after years of disappointment. Although these …
Amyloid-β-targeting immunotherapies for Alzheimer's disease
Y **, Q Du, M Song, R Kang, J Zhou, H Zhang… - Journal of Controlled …, 2024 - Elsevier
Recent advances in clinical passive immunotherapy have provided compelling evidence
that eliminating amyloid-β (Aβ) slows cognitive decline in Alzheimer's disease (AD) …
that eliminating amyloid-β (Aβ) slows cognitive decline in Alzheimer's disease (AD) …
Immune mechanisms and shared immune targets in neurodegenerative diseases
HL Weiner - Nature Reviews Neurology, 2024 - nature.com
The immune system plays a major part in neurodegenerative diseases. In some, such as
multiple sclerosis, it is the primary driver of the disease. In others, such as Alzheimer …
multiple sclerosis, it is the primary driver of the disease. In others, such as Alzheimer …
Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na+, K+-ATPase-Activating Antibody after Status Epilepticus
FK Mello, TB Sampaio, B Neuberger… - ACS Chemical …, 2024 - ACS Publications
Status epilepticus (SE) is a medical emergency associated with high mortality and morbidity.
Na+, K+-ATPase, is a promising therapeutic target for SE, given its critical role in regulation …
Na+, K+-ATPase, is a promising therapeutic target for SE, given its critical role in regulation …
Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer's disease
W Rui, Y Wu, Y Yang, W **e, D Qin, J Ming… - Journal of …, 2024 - Springer
Background It is now realized that peripheral inflammation and abnormal immune
responses, especially T cells, contribute to the development of Alzheimer's disease (AD) …
responses, especially T cells, contribute to the development of Alzheimer's disease (AD) …
[HTML][HTML] Microglia-Associated Neuroinflammation in Alzheimer's Disease and Its Therapeutic Potential
S Shah, H Jain - Neuroglia, 2024 - mdpi.com
Background: Neuroinflammation has long been implicated in the progression of amyloid
beta (Aβ) accumulation and the decline of cognitive function in Alzheimer's disease (AD) …
beta (Aβ) accumulation and the decline of cognitive function in Alzheimer's disease (AD) …
[PDF][PDF] Microglia-Associated Neuroinflammation in Alzheimer's
S Shah, H Jain - 2024 - researchgate.net
Background: Neuroinflammation has long been implicated in the progression of amyloid
beta (Aβ) accumulation and the decline of cognitive function in Alzheimer's disease (AD) …
beta (Aβ) accumulation and the decline of cognitive function in Alzheimer's disease (AD) …