Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB)
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …

Excessive hydrogen peroxide is harmful for almost all cell components, so its rapid and
efficient removal is of essential importance for aerobically living organisms. Conversely …

We recently reported the discovery of a lysine–cysteine redox switch in proteins with a
covalent nitrogen–oxygen–sulfur (NOS) bridge. Here, a systematic survey of the whole …

About thirty years ago the crystal structures of the heme catalases from Penicillium vitale
(PVC) and, a few months later, from bovine liver (BLC) were published. Both enzymes were …

Mycobacterium tuberculosis catalase‐peroxidase (KatG) is a bifunctional hemoprotein that
has been shown to activate isoniazid (INH), a pro‐drug that is integral to frontline …

Inhibition of the enzyme Mycobacterium tuberculosis InhA (enoyl-acyl carrier protein
reductase) due to formation of an isonicotinoyl-NAD adduct (IN-NAD) from isoniazid (INH) …

Bacteria and other living organisms offer a potentially unlimited resource for the discovery of
new chemical catalysts, but many interesting reaction phenotypes observed at the whole …

A mechanism accounting for the robust catalase activity in catalase-peroxidases (KatG)
presents a new challenge in heme protein enzymology. In Mycobacterium tuberculosis …

Lignocellulosic biomass is rich in lignins, which represent a bottomless natural source of
aromatic compounds. Due to the high chemical complexity of these aromatic polymers, their …

Heme proteins are crucial for biological systems by performing diverse functions. Nature has
evolved diverse approaches to fine-tune the structure and function of heme proteins, of …