Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

A hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and
hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the …

Deep single-cell multi-omic profiling offers a promising approach to understand and
overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here …

Metabolic reprogramming is a key alteration in tumorigenesis. In cancer cells, changes in
metabolic fluxes are required to cope with large demands on ATP, NADPH, and NADH, as …

Abstract Angiopoietin-1 (Ang-1) and Vascular Endothelial Growth Factor (VEGF) are central
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …

Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as
essential structural components of biological membranes but also provide energy and …

CD36, a multifunctional glycoprotein, has been shown to play critical roles in tumor initiation,
progression, metastasis, immune response, and drug resistance. CD36 serves as a receptor …

The combination of venetoclax (VEN) and azacitidine (AZA) has become the standard of
care for acute myeloid leukemia (AML) patients who are≥ 75 years or unfit for intensive …

Engineering immune cells to treat hematological malignancies has been a major focus of
research since the first resounding successes of CAR-T-cell therapies in B-ALL. Several …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common among children. AML is characterized by aberrant proliferation of …