Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of
tumor-related mortality. Endoscopy and serological tumor marker testing are currently the …

Objective This study aimed to explore the global burden of early-onset cancer based on the
Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid. Methods and analysis …

Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …

Importance Emerging data suggest that the incidence of early-onset cancers, defined as
cancers diagnosed in people younger than 50 years, is increasing, but updated data are …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Background The global status of women's health is underestimated, particularly the burden
on women of child-bearing age (WCBA). We aim to investigate the pattern and trend of …

Computational pathology refers to applying deep learning techniques and algorithms to
analyse and interpret histopathology images. Advances in artificial intelligence (AI) have led …

Background Trends in cancer incidence in recent birth cohorts largely reflect changes in
exposures during early life and foreshadow the future disease burden. Herein, we examined …