Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

SC Cunnane, E Trushina, C Morland… - Nature reviews Drug …, 2020 - nature.com
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Parkinson's disease and gut microbiota: from clinical to mechanistic and therapeutic studies

X Zhang, B Tang, J Guo - Translational Neurodegeneration, 2023 - Springer
Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. The
typical symptomatology of PD includes motor symptoms; however, a range of nonmotor …

Insulin signaling impairment in the brain as a risk factor in Alzheimer's disease

C Hölscher - Frontiers in aging neuroscience, 2019 - frontiersin.org
Type 2 diabetes is a risk factor for develo** Alzheimer's disease (AD). The underlying
mechanism that links up the two conditions seems to be the de-sensitization of insulin …

Effects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains

H Bektas, S Algul, F Altindag, K Yegin… - Journal of chemical …, 2022 - Elsevier
Diabetes, mobile phone use, and obesity have increased simultaneously in recent years.
The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the …

The emerging role of neuropeptides in Parkinson's disease

Y Zheng, L Zhang, J **e, L Shi - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Parkinson's disease (PD), the second most common age-related neurodegenerative
disease, results from the loss of dopamine neurons in the substantia nigra. This disease is …

The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice

HJ Huang, XR Chen, QQ Han, J Wang, A Pilot, R Yu… - …, 2019 - Elsevier
Ghrelin is an orexigenic hormone that also plays an important role in mood disorders. Our
previous studies demonstrated that ghrelin administration could protect against depression …

Acylated ghrelin as a multi-targeted therapy for Alzheimer's and Parkinson's disease

N Reich, C Hölscher - Frontiers in Neuroscience, 2020 - frontiersin.org
Much thought has been given to the impact of Amyloid Beta, Tau and Alpha-Synuclein in the
development of Alzheimer's disease (AD) and Parkinson's disease (PD), yet the clinical …

The interplay between ghrelin and microglia in neuroinflammation: implications for obesity and neurodegenerative diseases

C Russo, MS Valle, A Russo… - International Journal of …, 2022 - mdpi.com
Numerous studies have shown that microglia are capable of producing a wide range of
chemokines to promote inflammatory processes within the central nervous system (CNS) …

Ghrelin receptor signaling in health and disease: a biased view

JD Gross, Y Zhou, LS Barak, MG Caron - Trends in Endocrinology & …, 2023 - cell.com
As allosteric complexes, G-protein-coupled receptors (GPCRs) respond to extracellular
stimuli and pleiotropically couple to intracellular transducers to elicit signaling pathway …

Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway

H Wang, S Dou, J Zhu, Z Shao, C Wang, X Xu… - Neuropeptides, 2021 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder,
characterized by the loss of dopaminergic neurons in the substantia nigra and the …