The hallmarks of cancer immune evasion

C Galassi, TA Chan, I Vitale, L Galluzzi - Cancer Cell, 2024 - cell.com
According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer

E Buglakova, M Ekelöf, M Schwaiger-Haber… - Nature …, 2024 - nature.com
While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the
single-cell level remains a challenge. Here we present 13C-SpaceM, a method for spatial …

Lactylated apolipoprotein C‐II induces immunotherapy resistance by promoting extracellular lipolysis

J Chen, D Zhao, Y Wang, M Liu, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune
checkpoint inhibitors boost the survival of patients with non‐small‐cell lung cancer …

Review of eukaryote cellular membrane lipid Composition, with special attention to the fatty acids

O Ali, A Szabó - International Journal of Molecular Sciences, 2023 - mdpi.com
Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …

Plastic residues alter soil microbial community compositions and metabolite profiles under realistic conditions

D Dong, Z Guo, F Wu, X Yang, J Li - Science of The Total Environment, 2024 - Elsevier
Wide usage of plastic coupled with mismanagement has created a humongous
environmental hazard threatening entire ecosystems. To date, the potential effects of plastic …

Metabolic effects of ketogenic diets: exploring whole-body metabolism in connection with adipose tissue and other metabolic organs

Y Ahmad, DS Seo, Y Jang - International Journal of Molecular Sciences, 2024 - mdpi.com
The ketogenic diet (KD) is characterized by minimal carbohydrate, moderate protein, and
high fat intake, leading to ketosis. It is recognized for its efficiency in weight loss, metabolic …

Disorders of fatty acid homeostasis

FM Vaz, S Ferdinandusse, GS Salomons… - Journal of Inherited …, 2025 - Wiley Online Library
Humans derive fatty acids (FA) from exogenous dietary sources and/or endogenous
synthesis from acetyl‐CoA, although some FA are solely derived from exogenous sources …

Molecular drug simulation and experimental validation of the CD36 receptor competitively binding to Long-Chain fatty acids by 7-Ketocholesteryl-9-carboxynonanoate

C Fu, ML **ang, S Chen, G Dong, Z Liu, CB Chen… - ACS …, 2023 - ACS Publications
Long-chain fatty acids (LCFAs) are one of the main energy-supplying substances in the
body. LCFAs with different lengths and saturations may have contrasting biological effects …

The membrane domains of mammalian adenylyl cyclases are lipid receptors

M Landau, S Elsabbagh, H Gross, ACD Fuchs… - elife, 2024 - elifesciences.org
Abstract The biosynthesis of cyclic 3′, 5′-adenosine monophosphate (cAMP) by
mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G …