Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

We have made rapid progress in recent years in identifying the genetic causes of many
human diseases. However, despite this recent progress, our mechanistic understanding of …

Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies.
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer's disease
(AD). To address the underlying mechanism, we develop cerebral organoid models using …

Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …

Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-
binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase …

The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau
(oTau) are unknown. We have used Cry2-based optogenetics to induce tau oligomers (oTau …

Tau aggregates contribute to neurodegenerative diseases, including frontotemporal
dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro …

Cells form and use biomolecular condensates to execute biochemical reactions. The
molecular properties of non-membrane-bound condensates are directly connected to the …