The worldwide incidence of bone disorders and conditions has been increasing. Bone is a
nanomaterials composed of organic (mainly collagen) and inorganic (mainly nano …

Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Generation of pancreatic β cells from human pluripotent stem cells (hPSCs) holds promise
as a cell replacement therapy for diabetes. In this study, we establish a link between the …

Surface topography impacts on cell growth and differentiation, but it is not trivial to generate
defined surface structures and to assess the relevance of specific topographic parameters …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

Human tissues are sophisticated ensembles of many distinct cell types embedded in the
complex, but well-defined, structures of the extracellular matrix (ECM). Dynamic …

The chemistry, geometry, topography and mechanical properties of biomaterials modulate
biochemical signals (in particular ligand-receptor binding events) that control cells-matrix …

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of
stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with …

Chemical, mechanical, and topographic extracellular matrix (ECM) cues have been
extensively studied for their influence on cell behavior. These ECM cues alter cell adhesion …