Abstract Cyclin D2 (CCND2) is a critical cell cycle regulator and key member of the cyclin D2‐
CDK4 (DC) complex. De novo variants of CCND2 clustering in the distal part of the protein …

Simple Summary Here, we review the literature on Activating Enhancer-Binding Protein 4
(AP4)/transcription factor AP4 (TFAP4) function and regulation and its role in cancer …

It has been reported that the transcription factor activating enhancer-binding protein 4
(TFAP4) is upregulated and associated with an aggressive phenotype in several cancers …

DNA methylation plays a critical role in gene regulation by modulating the DNA binding of
transcription factors (TFs). This study integrates TFs' ChIP-seq profiles with WGBS profiles to …

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with
additional genetic lesions. While many of these cooperative genetic lesions have been …

Background PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-
5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in …

Early childhood tumours arise from transformed embryonic cells, which often carry large
copy number alterations (CNA). However, it remains unclear how CNAs contribute to …

Background Phosphoribosyl pyrophosphate synthetases 2 (PRPS2) is reported as an
oncogene in various cancers. However, the role of PRPS2 in cisplatin (DDP) resistance of …

Despite the identification of MYCN amplification as an adverse prognostic marker in
neuroblastoma, MYCN inhibitors have yet to be developed. Here, by integrating evidence …

Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7. 6.1) is a rate-limiting enzyme that
irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5 …