The repair of secondary critical bone defects is an international medical challenge. Bone
tissue engineering provides methods and technology for bone repair. The bone …

Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …

The material for bone scaffold replacement should be biocompatible and antibacterial to
prevent scaffold-associated infection. We biofunctionalized the hydroxyapatite (HA) …

Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and
bone health in many diseases and conditions; however, whether GSK3 should be targeted …

Bone grafting is commonly used as a treatment to repair bone defects. However, its use is
challenged by the presence of medical conditions that weaken the bone, like osteoporosis …

Background Growing evidence suggests that excessive inflammation hampers the
regenerative capacity of periodontal ligament cells (PDLCs) and that activation of the Wnt/β …

The field of transgender health has grown exponentially since the early 2010s. While this
increased visibility has not been without controversy, there is growing acknowledgement of …

Simulated microgravity (SMG) inhibits osteoblast differentiation (OBD) and induces bone
loss via the inhibition of the Wnt/β-catenin pathway. However, the mechanism by which SMG …

Importance Osteoporosis, a systemic skeletal disorder associated with substantial morbidity
and mortality, may be particularly common among individuals with bipolar disorder. Lithium …

Overproduction of reactive oxygen species (ROS) results in oxidative stress, a critical factor
in the pathogenesis of steroid‐induced osteonecrosis of the femoral head (SONFH). Excess …