Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress …

LJ Valotto Neto, M Reverete de Araujo… - Antioxidants, 2024 - mdpi.com
The aging of the global population has increased the prevalence of neurodegenerative
conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A …

Recent advances regarding the molecular mechanisms of triterpenic acids: A review (part I)

M Mioc, A Milan, D Malița, A Mioc, A Prodea… - International Journal of …, 2022 - mdpi.com
Triterpenic acids are phytocompounds with a widespread range of biological activities that
have been the subject of numerous in vitro and in vivo studies. However, their underlying …

[HTML][HTML] Discovery of multitarget-directed small molecule inhibitors from Andrographis paniculata for Nipah virus disease therapy: Molecular docking, molecular …

M Mandal, S Mandal - Chemical Physics Impact, 2024 - Elsevier
Nipah virus (NiV), an emerging highly infectious agent, causes fatal infection to humans
through zoonosis, particularly in Asian countries including India. No specific treatment or …

Cytotoxic activity of Amaryllidaceae plants against cancer cells: biotechnological, in vitro, and in silico approaches

L Trujillo, J Bedoya, N Cortés, EH Osorio, JC Gallego… - Molecules, 2023 - mdpi.com
Cancer is a major cause of death and an impediment to increasing life expectancy
worldwide. With the aim of finding new molecules for chemotherapeutic treatment of …

Phytochemicals as regulators of tumor glycolysis and hypoxia signaling pathways: evidence from in vitro studies

IE Pralea, AM Petrache, AB Tigu, D Gulei… - Pharmaceuticals, 2022 - mdpi.com
The full understanding of the complex nature of cancer still faces many challenges, as
cancers arise not as a result of a single target disruption but rather involving successive …

Eubacterium siraeum suppresses fat deposition via decreasing the tyrosine-mediated PI3K/AKT signaling pathway in high-fat diet-induced obesity

X Lai, S Liu, J Miao, R Shen, Z Wang, Z Zhang, H Gong… - Microbiome, 2024 - Springer
Background Obesity in humans can lead to chronic diseases such as diabetes and
cardiovascular disease. Similarly, subcutaneous fat (SCF) in pigs affects feed utilization, and …

Exploring molecular docking with MM-GBSA and molecular dynamics simulation to predict potent inhibitors of cyclooxygenase (COX-2) enzyme from terpenoid-based …

A Nayak, A Gadnayak, KT Dash, S Jena… - Journal of …, 2023 - Taylor & Francis
Abstract Cyclooxygenase 2 (COX-2), the key enzyme involved in prostaglandin (PGs)
production, is known to take part in inflammatory and immune responses. Though COX-2 …

Mitochondria in biology and medicine–2023

B Disha, RP Mathew, AB Dalal, AK Mahato… - Mitochondrion, 2024 - Elsevier
Mitochondria are an indispensable part of the cell that plays a crucial role in regulating
various signaling pathways, energy metabolism, cell differentiation, proliferation, and cell …

[HTML][HTML] A computational discovery of hexokinase 2 inhibitors from Newbouldia laevis for Hepatocellular carcinoma (HCC) treatment

HA Adekilekun, HA Oyewusi, RA Wahab… - South African Journal of …, 2024 - Elsevier
Newbouldia laevis, also known as the African Border Tree or Fever Tree, is a deciduous tree
native to West Africa. The plant is valued for its medicinal properties and is used in …

The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors

B Liu, Y Lu, A Taledaohan, S Qiao, Q Li, Y Wang - Molecules, 2023 - mdpi.com
Increased glycolysis is a key characteristic of malignant cells that contributes to their high
proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme …