Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells
(RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We …

Due to commonalities in pathophysiology, age-related macular degeneration (AMD)
represents a uniquely accessible model to investigate therapies for neurodegenerative …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Most irreversible blindness results from retinal disease. To advance our understanding of
the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to …

Age-related macular degeneration (AMD) is a leading cause of vision loss. To better
understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we …