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Multiple targets of the canonical WNT/β-catenin signaling in cancers
Y Lecarpentier, O Schussler, JL Hébert… - Frontiers in oncology, 2019 - frontiersin.org
Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the
formation and development of cancer cells. It plays a central role in three cyclic processes …
formation and development of cancer cells. It plays a central role in three cyclic processes …
Quantitative and logic modelling of molecular and gene networks
N Le Novere - Nature Reviews Genetics, 2015 - nature.com
Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …
properties of their individual components. Explanatory and predictive mathematical models …
Species-specific segmentation clock periods are due to differential biochemical reaction speeds
M Matsuda, H Hayashi, J Garcia-Ojalvo… - Science, 2020 - science.org
Although mechanisms of embryonic development are similar between mice and humans,
the time scale is generally slower in humans. To investigate these interspecies differences in …
the time scale is generally slower in humans. To investigate these interspecies differences in …
Use it or lose it to age: A review of bone and muscle communication
L Bonewald - Bone, 2019 - Elsevier
Until recently, it was assumed that the only interaction between muscle and bone is
mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism …
mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism …
Signalling dynamics in vertebrate segmentation
A Hubaud, O Pourquié - Nature reviews Molecular cell biology, 2014 - nature.com
Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …
establishes the metameric patterning of the body axis. This process involves the periodic …
Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves
A Goldbeter - … Transactions of the Royal Society A …, 2018 - royalsocietypublishing.org
The goal of this review article is to assess how relevant is the concept of dissipative structure
for understanding the dynamical bases of non-equilibrium self-organization in biological …
for understanding the dynamical bases of non-equilibrium self-organization in biological …
Oscillation quenching mechanisms: Amplitude vs. oscillation death
Oscillation quenching constitutes a fundamental emergent phenomenon in systems of
coupled nonlinear oscillators. Its importance for various natural and man-made systems …
coupled nonlinear oscillators. Its importance for various natural and man-made systems …
[HTML][HTML] Vertebrate segmentation: from cyclic gene networks to scoliosis
O Pourquié - Cell, 2011 - cell.com
One of the most striking features of the human vertebral column is its periodic organization
along the anterior-posterior axis. This pattern is established when segments of vertebrates …
along the anterior-posterior axis. This pattern is established when segments of vertebrates …
Understanding paraxial mesoderm development and sclerotome specification for skeletal repair
Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues.
However, a deep understanding of skeletal development is required in order to model this …
However, a deep understanding of skeletal development is required in order to model this …
Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate
AD Economou, A Ohazama, T Porntaveetus… - Nature …, 2012 - nature.com
We present direct evidence of an activator-inhibitor system in the generation of the regularly
spaced transverse ridges of the palate. We show that new ridges, called rugae, that are …
spaced transverse ridges of the palate. We show that new ridges, called rugae, that are …