REV-ERB and ROR nuclear receptors as drug targets

DJ Kojetin, TP Burris - Nature reviews Drug discovery, 2014 - nature.com
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

Circadian etiology of type 2 diabetes mellitus

N Javeed, AV Matveyenko - Physiology, 2018 - journals.physiology.org
The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

[HTML][HTML] Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells

J Yang, M Vamvini, P Nigro, LL Ho, K Galani, M Alvarez… - Cell metabolism, 2022 - cell.com
Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …

The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

G Manella, E Sabath, R Aviram, V Dandavate… - Nature …, 2021 - nature.com
The mammalian circadian system consists of a central clock in the brain that synchronizes
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …

High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women

D Jakubowicz, M Barnea, J Wainstein, O Froy - Obesity, 2013 - Wiley Online Library
Objective Few studies examined the association between time‐of‐day of nutrient intake and
the metabolic syndrome. Our goal was to compare a weight loss diet with high caloric intake …

The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms

A Briançon-Marjollet, M Weiszenstein, M Henri… - Diabetology & metabolic …, 2015 - Springer
Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened
over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally …

[HTML][HTML] High-fat diet disrupts behavioral and molecular circadian rhythms in mice

A Kohsaka, AD Laposky, KM Ramsey, C Estrada… - Cell metabolism, 2007 - cell.com
The circadian clock programs daily rhythms and coordinates multiple behavioral and
physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent …

[HTML][HTML] Circadian control of glucose metabolism

A Kalsbeek, S la Fleur, E Fliers - Molecular metabolism, 2014 - Elsevier
The incidence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic
proportions. The pathophysiology of T2DM is complex and involves insulin resistance …

Obesity and shift work: chronobiological aspects

LC Antunes, R Levandovski, G Dantas… - Nutrition research …, 2010 - cambridge.org
The present review has the objective of summarising chronobiological aspects of shift work
and obesity. There was a systematic search in PubMed databases, using the following …

The meter of metabolism

CB Green, JS Takahashi, J Bass - Cell, 2008 - cell.com
The circadian system orchestrates the temporal organization of many aspects of physiology,
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …