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REV-ERB and ROR nuclear receptors as drug targets
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
Circadian etiology of type 2 diabetes mellitus
The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …
[HTML][HTML] Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells
Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …
mechanisms remain incompletely understood given the challenge of profiling …
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding
The mammalian circadian system consists of a central clock in the brain that synchronizes
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …
clocks in the peripheral tissues. Although the hierarchy between central and peripheral …
High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women
D Jakubowicz, M Barnea, J Wainstein, O Froy - Obesity, 2013 - Wiley Online Library
Objective Few studies examined the association between time‐of‐day of nutrient intake and
the metabolic syndrome. Our goal was to compare a weight loss diet with high caloric intake …
the metabolic syndrome. Our goal was to compare a weight loss diet with high caloric intake …
The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms
Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened
over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally …
over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally …
[HTML][HTML] High-fat diet disrupts behavioral and molecular circadian rhythms in mice
A Kohsaka, AD Laposky, KM Ramsey, C Estrada… - Cell metabolism, 2007 - cell.com
The circadian clock programs daily rhythms and coordinates multiple behavioral and
physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent …
physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent …
[HTML][HTML] Circadian control of glucose metabolism
The incidence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic
proportions. The pathophysiology of T2DM is complex and involves insulin resistance …
proportions. The pathophysiology of T2DM is complex and involves insulin resistance …
Obesity and shift work: chronobiological aspects
The present review has the objective of summarising chronobiological aspects of shift work
and obesity. There was a systematic search in PubMed databases, using the following …
and obesity. There was a systematic search in PubMed databases, using the following …
The meter of metabolism
The circadian system orchestrates the temporal organization of many aspects of physiology,
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …