Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis
The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the
World Health Organization. Challenges arise concerning how to optimally support the …
World Health Organization. Challenges arise concerning how to optimally support the …
The future of cancer immunotherapy: microenvironment-targeting combinations
YR Murciano-Goroff, AB Warner, JD Wolchok - Cell research, 2020 - nature.com
Immunotherapy holds the potential to induce durable responses, but only a minority of
patients currently respond. The etiologies of primary and secondary resistance to …
patients currently respond. The etiologies of primary and secondary resistance to …
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression
E Yang, X Wang, Z Gong, M Yu, H Wu… - Signal transduction and …, 2020 - nature.com
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment
M Marzagalli, ND Ebelt, ER Manuel - Seminars in cancer biology, 2019 - Elsevier
Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …
rapidly increasing in the past decades. Melanomas are among the most immunogenic …
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
Tumor-driven immune suppression is a major barrier to successful immunotherapy in
ovarian carcinomas (OvCa). Among various mechanisms responsible for immune …
ovarian carcinomas (OvCa). Among various mechanisms responsible for immune …
Adaptive mechanisms of tumor therapy resistance driven by tumor microenvironment
Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …
strategies have been developed for various cancers, including chemotherapy, radiotherapy …
The relationship between nutrition and the immune system
C Munteanu, B Schwartz - Frontiers in nutrition, 2022 - frontiersin.org
Nutrition plays an essential role in the regulation of optimal immunological response, by
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …
Immune checkpoint inhibitors: The linchpins of modern immunotherapy
BA Wilky - Immunological reviews, 2019 - Wiley Online Library
Immune checkpoint inhibitors (ICIs) have revolutionized our approach to cancer treatment in
the past decade. While monoclonal antibodies to CTLA‐4 and PD‐1/PD‐L1 have produced …
the past decade. While monoclonal antibodies to CTLA‐4 and PD‐1/PD‐L1 have produced …
Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome
The immunological mechanisms underlying the clinical presentation of SARS-CoV-2
infection and those influencing the disease outcome remain to be defined. Myeloid-derived …
infection and those influencing the disease outcome remain to be defined. Myeloid-derived …
Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth
D Doleschel, S Hoff, S Koletnik, A Rix, D Zopf… - Journal of Experimental …, 2021 - Springer
Background Patients with advanced colorectal cancer (CRC) have a poor prognosis.
Combinations of immunotherapies and anti-angiogenic agents are currently being …
Combinations of immunotherapies and anti-angiogenic agents are currently being …