Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …

Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Diverse RNAs and RNA-binding proteins form phase-separated, membraneless granules in
cells under stress conditions. However, the role of the prevalent mRNA methylation, m6A …

The spatiotemporal organization and dynamics of chromatin play critical roles in regulating
genome function. However, visualizing specific, endogenous genomic loci remains …

As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information
is generally carried on a circular chromosome with a single origin of replication from which …

Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

Transcription of highly expressed genes has been shown to occur in stochastic bursts. But
the origin of such ubiquitous phenomenon has not been understood. Here, we present the …

Advances in imaging technologies have revealed that many bacteria possess organelles
with a proteomically defined lumen and a macromolecular boundary. Some are bound by a …

Super-resolution microscopy (SRM) methods have allowed scientists to exceed the
diffraction limit of light, enabling the discovery and investigation of cellular structures at the …