Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic
phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+ …

The roles played by cholesterol in cancer development and the potential of therapeutically
targeting cholesterol homeostasis is a controversial area in the cancer community. Several …

ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic caused by the Severe
Acute Respiratory Syndrome Related Coronavirus 2 (SARS-CoV-2) is a global health …

Annexins constitute an evolutionary conserved multigene protein superfamily characterized
by their ability to interact with biological membranes in a calcium dependent manner. They …

Caveolae are long-lived plasma membrane microdomains composed of caveolins, cavins,
and a cholesterol-rich membrane. Little is known about how caveolae disassemble and how …

We analyzed the assembly of caveolae in CV1 cells by following the fate of newly
synthesized caveolin‐1 (CAV1), caveolin‐2 and polymerase I and transcript release factor …

Mammalian cells acquire most exogenous cholesterol through receptor‐mediated
endocytosis of low‐density lipoproteins (LDLs). After internalization, LDL cholesteryl esters …

Background The protein annexin A6 (AnxA6) is involved in numerous membrane-related
biological processes including cell migration and invasion by interacting with other proteins …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …

Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick
type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a …