Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …

DNA damage has been long recognized as causal factor for cancer development. When
erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes …

The fractal globule is a compact polymer state that emerges during polymer condensation as
a result of topological constraints which prevent one region of the chain from passing across …

BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …

The cellular DNA-damage response is a signaling network that is vigorously activated by
cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB response is …

The colinearity of genes in Hox clusters suggests a role for chromosome structure in gene
regulation. We reveal programmed changes in chromatin structure and nuclear organization …

Women with inherited mutations in the BRCA1 gene have increased risk of develo**
breast cancer but also exhibit a predisposition for the development of aggressive basal-like …

Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …

We present an analysis of chromatin fiber structure across the human genome. Compact
and open chromatin fiber structures were separated by sucrose sedimentation and their …