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Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …
Cytokine-skewed Tfh cells: functional consequences for B cell help
CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
Interleukin 17 is a chief orchestrator of immunity
Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …
cytokine is a central player in immunity at the sites most exposed to microorganisms …
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …
defense, but are also major contributors to pathology of autoimmune and inflammatory …
Modulating Th2 cell immunity for the treatment of asthma
It is estimated that more than 339 million people worldwide suffer from asthma. The leading
cause of asthma development is the breakdown of immune tolerance to inhaled allergens …
cause of asthma development is the breakdown of immune tolerance to inhaled allergens …
Targeting IL-17 and TH17 cells in chronic inflammation
The key role of interleukin-17 (IL-17) and T helper 17 (TH17) cells in tissue inflammation,
autoimmunity and host defence led to the experimental targeting of these molecules in …
autoimmunity and host defence led to the experimental targeting of these molecules in …
Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease
The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …
Germinal centers
Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …
Pathogenesis of human systemic lupus erythematosus: a cellular perspective
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …
organs. A complex interaction of genetics, environment, and hormones leads to immune …
Follicular Helper CD4 T Cells (TFH)
T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …