Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Recent advances in SELEX technology and aptamer applications in biomedicine

Z Zhuo, Y Yu, M Wang, J Li, Z Zhang, J Liu… - International journal of …, 2017 - mdpi.com
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with
high affinity and specificity. The process of selecting an aptamer is called Systematic …

Aptamer-conjugated extracellular nanovesicles for targeted drug delivery

Y Wan, L Wang, C Zhu, Q Zheng, G Wang, J Tong… - Cancer …, 2018 - aacrjournals.org
Extracellular nanovesicles (ENV) released by many cells contain lipids, proteins, and
nucleic acids that contribute to intercellular communication. ENVs have emerged as …

Aptamer in bioanalytical applications

AB Iliuk, L Hu, WA Tao - Analytical chemistry, 2011 - ACS Publications
(2009À2010), thefield of aptamer research has continuously generated lots of interest in the
scientific community. Aptamers, first reported by three groups independently in 1990, 1À3 …

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes

Y Wan, G Cheng, X Liu, SJ Hao, M Nisic… - Nature biomedical …, 2017 - nature.com
Extracellular vesicles (EVs) can mediate intercellular communication by transferring cargo
proteins and nucleic acids between cells. The pathophysiological roles and clinical value of …

Selection and biosensor application of aptamers for small molecules

F Pfeiffer, G Mayer - Frontiers in chemistry, 2016 - frontiersin.org
Small molecules play a major role in the human body and as drugs, toxins, and chemicals.
Tools to detect and quantify them are therefore in high demand. This review will give an …

Nucleic acid aptamers in cancer research, diagnosis and therapy

H Ma, J Liu, MM Ali, MAI Mahmood… - Chemical Society …, 2015 - pubs.rsc.org
Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …

Bioinspired multivalent DNA network for capture and release of cells

W Zhao, CH Cui, S Bose, D Guo, C Shen… - Proceedings of the …, 2012 - pnas.org
Capture and isolation of flowing cells and particulates from body fluids has enormous
implications in diagnosis, monitoring, and drug testing, yet monovalent adhesion molecules …

[HTML][HTML] Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid …

A Kowalik, M Kowalewska, S Góźdź - Translational Research, 2017 - Elsevier
Eight million people die of cancer each year and 90% of deaths are caused by systemic
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …

DNA nanolithography enables a highly ordered recognition interface in a microfluidic chip for the efficient capture and release of circulating tumor cells

J Zhang, B Lin, L Wu, M Huang, X Li… - Angewandte …, 2020 - Wiley Online Library
Microfluidic chips with nano‐scale structures have shown great potential, but the fabrication
and cost issues restrict their application. Herein, we propose a conceptually new “DNA …