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Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation
Most cognitive functions involving the prefrontal cortex emerge during late development.
Increasing evidence links this delayed maturation to the protracted timeline of prefrontal …
Increasing evidence links this delayed maturation to the protracted timeline of prefrontal …
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …
Profiling cell-type specific gene expression in post-mortem human brain samples through laser capture microdissection
The transcriptome of a cell constitutes an essential piece of cellular identity and contributes
to the multifaceted complexity and heterogeneity of cell-types within the mammalian brain …
to the multifaceted complexity and heterogeneity of cell-types within the mammalian brain …
Common changes in rat cortical gene expression after valproate or lithium treatment particularly affect pre-and post-synaptic pathways that regulate four …
Objectives We have postulated that common changes in gene expression after treatment
with different therapeutic classes of psychotropic drugs contribute to their common …
with different therapeutic classes of psychotropic drugs contribute to their common …
Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia
Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of
differentially expressed genes. However, the extent to which these gene expression …
differentially expressed genes. However, the extent to which these gene expression …
Lower levels of kainate receptors, but not AMPA or NMDA receptors, in Brodmann's area (BA) 9, but not BA 10, from a subgroup of people with schizophrenia who …
In a previous study on ionotropic glutamate receptors, we have shown that [3 H] kainate, but
not [3 H] AMPA or [3 H] NMDA, receptor binding was lower in Brodmann's area (BA) 9 from …
not [3 H] AMPA or [3 H] NMDA, receptor binding was lower in Brodmann's area (BA) 9 from …
Molecular neurobiology of loss: A role for basolateral amygdala extracellular matrix
Psychological loss is a common experience that erodes well-being and negatively impacts
quality of life. The molecular underpinnings of loss are poorly understood. Here, we …
quality of life. The molecular underpinnings of loss are poorly understood. Here, we …
Interpreting and visualizing pathway analyses using embedding representations with PAVER
Omics studies use large-scale high-throughput data to explain changes underlying different
traits or conditions. However, omics analysis often results in long lists of pathways that are …
traits or conditions. However, omics analysis often results in long lists of pathways that are …
Evidence that a working memory cognitive phenotype within schizophrenia has a unique underlying biology.
It is suggested studying phenotypes within the syndrome of schizophrenia will accelerate
understanding the complex molecular pathology of the disorder. Supporting this hypothesis …
understanding the complex molecular pathology of the disorder. Supporting this hypothesis …
Neuronal alterations in AKT isotype expression in schizophrenia
Schizophrenia is characterized by substantial alterations in brain function, and previous
studies suggest insulin signaling pathways, particularly involving AKT, are implicated in the …
studies suggest insulin signaling pathways, particularly involving AKT, are implicated in the …