Targeting the voltage-dependent K+ channels Kv1. 3 and Kv1. 5 as tumor biomarkers for cancer detection and prevention
A Felipe, J Bielanska, N Comes… - Current medicinal …, 2012 - ingentaconnect.com
Potassium channels (KCh) are a diverse group of membrane proteins that participate in the
control of the membrane potential. More than eighty different KCh genes have been …
control of the membrane potential. More than eighty different KCh genes have been …
IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia. Anti-arrhythmic drugs
remain the mainstay of therapy, but the available class I and III anti-arrhythmic drugs are …
remain the mainstay of therapy, but the available class I and III anti-arrhythmic drugs are …
Assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine using the CiPA concept
Chloroquine and hydroxychloroquine have been proposed recently as therapy for SARS-
CoV-2-infected patients, but during 3 months of extensive use concerns were raised related …
CoV-2-infected patients, but during 3 months of extensive use concerns were raised related …
Drug-induced QT/QTc interval shortening: lessons from drug-induced QT/QTc prolongation
M Malik - Drug safety, 2016 - Springer
The review discusses safety implications of drugs found to shorten the QT/QTc interval. It
uses parallels with drug-induced QT/QTc prolongation. It summarizes the evidence that …
uses parallels with drug-induced QT/QTc prolongation. It summarizes the evidence that …
Coupling of excitation to Ca2+ release is modulated by dysferlin
V Lukyanenko, JM Muriel… - The Journal of Physiology, 2017 - Wiley Online Library
Key points Dysferlin, the protein missing in limb girdle muscular dystrophy 2B and Miyoshi
myopathy, concentrates in transverse tubules of skeletal muscle, where it stabilizes voltage …
myopathy, concentrates in transverse tubules of skeletal muscle, where it stabilizes voltage …
Intravenous anesthetic propofol inhibits multiple human cardiac potassium channels.
Background Propofol is widely used clinically for the induction and maintenance of
anesthesia. Clinical case reports have shown that propofol has an antiatrial …
anesthesia. Clinical case reports have shown that propofol has an antiatrial …
The potential role of Kv4.3 K+ channel in heart hypertrophy
R Huo, Y Sheng, WT Guo, DL Dong - Channels, 2014 - Taylor & Francis
Transient outward K+ current (Ito) plays a crucial role in the early phase of cardiac action
potential repolarization. Kv4. 3 K+ channel is an important component of Ito. The function …
potential repolarization. Kv4. 3 K+ channel is an important component of Ito. The function …
Open channel block of the fast transient outward K+ current by primaquine and chloroquine in rat left ventricular cardiomyocytes
M Wagner, KG Riepe, E Eberhardt, T Volk - European journal of …, 2010 - Elsevier
Anti-malarial drugs may have severe adverse cardiac effects as a result of their ion channel
blocking properties. Here we investigate the effect of the aminoquinolines primaquine and …
blocking properties. Here we investigate the effect of the aminoquinolines primaquine and …
Spironolactone and its main metabolite canrenoic acid block hKv1. 5, Kv4. 3 and Kv7. 1+ minK channels
Both spironolactone (SP) and its main metabolite, canrenoic acid (CA), prolong cardiac
action potential duration and decrease the Kv11. 1 (HERG) current. We examined the effects …
action potential duration and decrease the Kv11. 1 (HERG) current. We examined the effects …
Inhibition of cardiac Kv1. 5 and Kv4. 3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action
F Fischer, N Vonderlin, E Zitron, C Seyler… - Naunyn-Schmiedeberg's …, 2013 - Springer
Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of
Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. For ajmaline …
Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. For ajmaline …