Dietary natural products as inhibitors of α-amylase and α-glucosidase: an updated review of ligand-receptor correlations validated by docking studies
M Rangel-Galván, Y Pacheco-Hernández… - Food Bioscience, 2024 - Elsevier
A therapeutic strategy to treat Type 2 diabetes mellitus (T2D) is focused on controlling
postprandial glucose levels by inhibiting α-amylase and α-glucosidase. These enzymes are …
postprandial glucose levels by inhibiting α-amylase and α-glucosidase. These enzymes are …
Inhibition mechanism of buckwheat hulls polyphenols on α-amylase and α-glucosidase using kinetics, spectroscopics and molecular docking approaches
C Xu, M He, Z Jiang, Q Yang - International Journal of Biological …, 2024 - Elsevier
The work investigated the activity inhibition of phenolic compounds in buckwheat
(Fagopyrum esculentum Moench) hulls (BH) on α-amylase and α-glucosidase, and clarified …
(Fagopyrum esculentum Moench) hulls (BH) on α-amylase and α-glucosidase, and clarified …
The substitution sites of hydroxyl and galloyl groups determine the inhibitory activity of human pancreatic α-amylase in twelve tea polyphenol monomers
Tea polyphenols have been reported as potential α-amylase inhibitors. However, the
quantitative structure–activity relationship (QSAR) between tea polyphenols and human …
quantitative structure–activity relationship (QSAR) between tea polyphenols and human …
Ascorbic and salicylic acids modulate the binding interactions of an emergency contraceptive pill levonorgestrel to a model transport protein: Insights from …
Serum proteins generally help to transport and distribute drug molecules within the body. In
this study, the binding characteristics of bovine serum albumin (BSA) with levonorgestrel …
this study, the binding characteristics of bovine serum albumin (BSA) with levonorgestrel …
In Vitro Inhibitory Effects of Polyphenols from Flos sophorae immaturus on α-Glucosidase: Action Mechanism, Isothermal Titration Calorimetry and Molecular Docking …
Y Gong, J Li, J Li, L Wang, L Fan - Foods, 2023 - mdpi.com
Flos sophorae immaturus (FSI) is considered to be a natural hypoglycemic product with the
potential for a-glucosidase inhibitory activity. In this work, the polyphenols with α …
potential for a-glucosidase inhibitory activity. In this work, the polyphenols with α …
The inhibitory mechanism of pentacyclic triterpenoid acids on pancreatic lipase and cholesterol esterase
H Shen, J Wang, J Ao, L Ye, Y Shi, Y Liu, M Li, A Luo - Food Bioscience, 2023 - Elsevier
Inhibiting pancreatic Lipase (PL) and cholesterol esterase (CEase) can effectively control
blood triglycerides and cholesterol levels. The interaction characteristics of pentacyclic …
blood triglycerides and cholesterol levels. The interaction characteristics of pentacyclic …
Digestibility modulating and 3D printing of gliadin/resveratrol nanoparticle-filled starch gels
W Lv, L Zhang, M Zhang, X Liu, Y Zhou, Y Wang - Food Chemistry, 2025 - Elsevier
This study assessed the impact of resveratrol-loaded gliadin nanoparticles on starch
digestibility and explored their potential for 3D printing. The starch hydrolysis was …
digestibility and explored their potential for 3D printing. The starch hydrolysis was …
Synthesis of ECG ((−)-epicatechin gallate) acylated derivatives as new inhibitors of α-amylase and their mechanism on delaying starch digestion
S Wang, C Jiang, H **g, X Du, S Zhu, H Wang, C Ma - Food Bioscience, 2023 - Elsevier
Epicatechin gallate (ECG), as a natural α-amylase inhibitor, has received extensive
attention. However, poor liposolubility of ECG limits its application. In this study, lipophilic …
attention. However, poor liposolubility of ECG limits its application. In this study, lipophilic …
Identification of two novel α-amylase inhibitory activity peptide from Russian sea cucumber body wallprotein hydrolysate
GX Chen, X Ge, Y Sun, W Sui, Y **, J Geng… - International Journal of …, 2025 - Elsevier
This study aimed to identify novel α-amylase inhibitory peptides from Russian sea
cucumbers and elucidate their inhibitory mechanisms. Among the 52 identified sea …
cucumbers and elucidate their inhibitory mechanisms. Among the 52 identified sea …
Characterization of the chemical profiles and biological activities of Thesium bertramii Azn. Extracts using a combination of in vitro, in silico, and network …
Abstract The genus Thesium, family Santalaceae, comprises about 350 species, and,
although many of them are used as functional food and in traditional medicine, there are …
although many of them are used as functional food and in traditional medicine, there are …