Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

Establishing and regulating the composition of cilia for signal transduction

MV Nachury, DU Mick - Nature reviews Molecular cell biology, 2019 - nature.com
The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

[PDF][PDF] COVID-19: attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit heme metabolism

W Liu, H Li - Am Chem Soc, 2020 - pdfs.semanticscholar.org
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by
the novel coronavirus. The virus is the positive-strand RNA one with high homology to bat …

Imaging extracellular vesicles: current and emerging methods

STY Chuo, JCY Chien, CPK Lai - Journal of biomedical science, 2018 - Springer
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They
range from 30 nm to several micrometers in diameter, and ferry biological cargos such as …

Fruit‐Derived Extracellular‐Vesicle‐Engineered Structural Droplet Drugs for Enhanced Glioblastoma Chemotherapy

J Chen, J Pan, S Liu, Y Zhang, S Sha, H Guo… - Advanced …, 2023 - Wiley Online Library
Existing solid‐nanoparticle‐based drug delivery systems remain a great challenge for
glioblastoma chemotherapy due to their poor capacities in crossing the blood–brain …

An actin network dispatches ciliary GPCRs into extracellular vesicles to modulate signaling

AR Nager, JS Goldstein, V Herranz-Pérez, D Portran… - Cell, 2017 - cell.com
Signaling receptors dynamically exit cilia upon activation of signaling pathways such as
Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to …

The emerging role of exosomes in innate immunity, diagnosis and therapy

P Gangadaran, H Madhyastha, R Madhyastha… - Frontiers in …, 2023 - frontiersin.org
Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining
homeostasis by exchanging genetic or metabolic information between different cells …

The pathogenesis of African trypanosomiasis

E Pays, M Radwanska, S Magez - Annual Review of Pathology …, 2023 - annualreviews.org
African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause slee** sickness. Long-lasting infection is required to favor …

[HTML][HTML] Extracellular vesicles: Critical players during cell migration

BH Sung, CA Parent, AM Weaver - Developmental cell, 2021 - cell.com
Cell migration is essential for the development and maintenance of multicellular organisms,
contributing to embryogenesis, wound healing, immune response, and other critical …

Antiparasitics in animal health: quo vadis?

PM Selzer, C Epe - Trends in parasitology, 2021 - cell.com
Antiparasitics acting on endo-or ectoparasites represent the second largest segment of the
global animal health market, accounting for 23% of market share. However, relatively few …