Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

As global life expectancy increases, age-related brain diseases such as stroke and
dementia have become leading causes of death and disability. The aging of the …

Age-related impairment of neurovascular coupling (NVC;“functional hyperemia”) is a critical
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …

The intricate interplay between cellular senescence and alterations in the gut microbiome
emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to …

The inexorability of the aging process has sparked the curiosity of human beings since
ancient times. However, despite this interest and the extraordinary scientific advances in the …

Vascular cognitive impairment (VCI) traditionally encompasses a variety of cerebrovascular
pathologies that contribute to varying levels of cognitive impairment, ranging from subtle to …

The mammalian nervous system is impacted by aging. Aging alters brain architecture, is
associated with molecular damage, and can manifest with cognitive and motor deficits that …

Age-related cerebromicrovascular changes, including blood-brain barrier (BBB) disruption
and microvascular rarefaction, play a significant role in the development of vascular …

Heterochronic parabiosis consists of surgically connecting the circulatory systems of a
young and an old animal. This technique serves as a model to study circulating factors that …

The global issue of aging populations has become increasingly prominent, thus the
research and development for anti-aging therapies to assure longevity as well as to …