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A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals
Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …
Kynurenines in the CNS: recent advances and new questions
Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases
Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …
Mechanistic conformational and substrate selectivity profiles emerging in the evolution of enzymes via parallel trajectories
Laboratory evolution studies have demonstrated that parallel evolutionary trajectories can
lead to genetically distinct enzymes with high activity towards a non-preferred substrate …
lead to genetically distinct enzymes with high activity towards a non-preferred substrate …
Leveraging intrinsic flexibility to engineer enhanced enzyme catalytic activity
CS Karamitros, K Murray, B Winemiller, C Lamb… - Proceedings of the …, 2022 - pnas.org
Dynamic motions of enzymes occurring on a broad range of timescales play a pivotal role in
all steps of the reaction pathway, including substrate binding, catalysis, and product release …
all steps of the reaction pathway, including substrate binding, catalysis, and product release …
Kynurenine pathway metabolites and enzymes involved in redox reactions
DG Esquivel, D Ramírez-Ortega, B Pineda, N Castro… - …, 2017 - Elsevier
Oxido-reduction reactions are a fundamental part of the life due to support many vital
biological processes as cellular respiration and glucose oxidation. In the redox reactions …
biological processes as cellular respiration and glucose oxidation. In the redox reactions …
Of mice, rats and men: revisiting the quinolinic acid hypothesis of Huntington's disease
R Schwarcz, P Guidetti, KV Sathyasaikumar… - Progress in …, 2010 - Elsevier
The neurodegenerative disease Huntington's disease (HD) is caused by an expanded
polyglutamine (polyQ) tract in the protein huntingtin (htt). Although the gene encoding htt …
polyglutamine (polyQ) tract in the protein huntingtin (htt). Although the gene encoding htt …
Tryptophan metabolism in atherosclerosis and diabetes
E Sudar-Milovanovic, Z Gluvic… - Current medicinal …, 2022 - benthamdirect.com
The essential amino acid tryptophan (Trp) undergoes catabolism through several pathways,
producing biologically active metabolites that significantly impact physiological processes …
producing biologically active metabolites that significantly impact physiological processes …
Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme
The Trp metabolite l-kynurenine (KYN) accumulates in numerous solid tumours and
mediates potent immunosuppression. Bacterial kynureninases (KYNases), which …
mediates potent immunosuppression. Bacterial kynureninases (KYNases), which …
Chemistry and diversity of pyridoxal-5′-phosphate dependent enzymes
RS Phillips - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2015 - Elsevier
Abstract Pyridoxal-5′-phosphate (PLP) is a versatile cofactor that enzymes use to catalyze
a wide variety of reactions of amino acids, including transamination, decarboxylation …
a wide variety of reactions of amino acids, including transamination, decarboxylation …