Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
A decade of transcription factor-mediated reprogramming to pluripotency
K Takahashi, S Yamanaka - Nature reviews Molecular cell biology, 2016 - nature.com
The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
Chemically defined generation of human cardiomyocytes
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …
efficient but require complex, undefined medium constituents that hinder further elucidation …
Chemically defined conditions for human iPSC derivation and culture
We re-examine the individual components for human embryonic stem cell (ESC) and
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
F Anokye-Danso, CM Trivedi, D Juhr, M Gupta, Z Cui… - Cell stem cell, 2011 - cell.com
Transcription factor-based cellular reprogramming has opened the way to converting
somatic cells to a pluripotent state, but has faced limitations resulting from the requirement …
somatic cells to a pluripotent state, but has faced limitations resulting from the requirement …
[HTML][HTML] Chemically induced reprogramming to reverse cellular aging
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
Induced pluripotency: history, mechanisms, and applications
M Stadtfeld, K Hochedlinger - Genes & development, 2010 - genesdev.cshlp.org
The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Protein lysine acetylation by p300/CBP
Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …
[HTML][HTML] Epigenetics: a new bridge between nutrition and health
Nutrients can reverse or change epigenetic phenomena such as DNA methylation and
histone modifications, thereby modifying the expression of critical genes associated with …
histone modifications, thereby modifying the expression of critical genes associated with …