A size-dependent division strategy accounts for leukemia cell size heterogeneity

M Miotto, S Scalise, M Leonetti, G Ruocco… - Communications …, 2024 - nature.com
Heterogeneity in the size distribution of cancer cell populations is linked to drug resistance
and invasiveness. However, understanding how such heterogeneity arises is still damped …

Cell size distribution of lineage data: analytic results and parameter inference

C Jia, A Singh, R Grima - Iscience, 2021 - cell.com
Recent advances in single-cell technologies have enabled time-resolved measurements of
the cell size over several cell cycles. These data encode information on how cells correct …

A population-based approach to study the effects of growth and division rates on the dynamics of cell size statistics

N Totis, C Nieto, A Küper… - IEEE Control …, 2020 - ieeexplore.ieee.org
The dynamics of the size distribution in growing and dividing rod-shaped bacteria can
change depending on the perspective through which the cell population is observed. From …

Pyecolib: a python library for simulating stochastic cell size dynamics

C Nieto, SC Blanco, C Vargas-García, A Singh… - Physical …, 2023 - iopscience.iop.org
Recently, there has been an increasing need for tools to simulate cell size regulation due to
important applications in cell proliferation and gene expression. However, implementing the …

Feedbacks between size and density determine rapid eco‐phenotypic dynamics

JP Gibert, ZY Han, DJ Wieczynski, S Votzke… - Functional …, 2022 - Wiley Online Library
Body size is a fundamental trait linked to many ecological processes—from individuals to
ecosystems. Although the effects of body size on metabolism are well‐known, the potential …

Stochastic chemical kinetics of cell fate decision systems: From single cells to populations and back

J Ruess, G Ballif, C Aditya - The Journal of Chemical Physics, 2023 - pubs.aip.org
Stochastic chemical kinetics is a widely used formalism for studying stochasticity of chemical
reactions inside single cells. Experimental studies of reaction networks are generally …

Characterizing non-exponential growth and bimodal cell size distributions in fission yeast: An analytical approach

C Jia, A Singh, R Grima - PLOS Computational Biology, 2022 - journals.plos.org
Unlike many single-celled organisms, the growth of fission yeast cells within a cell cycle is
not exponential. It is rather characterized by three distinct phases (elongation, septation, and …

Coupling cell size regulation and proliferation dynamics of C. glutamicum reveals cell division based on surface area

C Nieto, S Täuber, L Blöbaum, Z Vahdat… - …, 2023 - pmc.ncbi.nlm.nih.gov
Single cells actively coordinate growth and division to regulate their size, yet how this size
homeostasis at the single-cell level propagates over multiple generations to impact clonal …

Continuous rate modeling of bacterial stochastic size dynamics

C Nieto, C Vargas-Garcia, JM Pedraza - Physical Review E, 2021 - APS
Bacterial division is an inherently stochastic process with effects on fluctuations of protein
concentration and phenotype variability. Current modeling tools for the stochastic short-term …

Cell size control shapes fluctuations in colony population

C Nieto, C Vargas-García, JM Pedraza… - 2022 IEEE 61st …, 2022 - ieeexplore.ieee.org
Exponentially growing cells regulate their size by controlling their timing of division. Since
two daughter cells are born as a result of this cell splitting, cell size regulation has a direct …