Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug
delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive …

Optical microscopes are an important imaging tool that have effectively advanced the
development of modern biomedicine. In recent years, super-resolution microscopy (SRM) …

Mitochondria are highly dynamic organelles whose fragmentation by fission is critical to their
functional integrity and cellular homeostasis. Here, we develop a method via optogenetic …

The liver cancer has microenvironmental features such as low pH, M2 tumor-associated
macrophage enrichment, low oxygen, rich blood supply and susceptibility to hematotropic …

With the progression of nanotechnology, a growing number of nanomaterials have been
created and incorporated into organisms and ecosystems, which raises significant concern …

As the central role in maintaining physiological homeostasis, tracking the autophagy in living
cells is highly desired in biological research and pharmacologic development. Herein, a …

Endolysosome dynamics plays an important role in autophagosome biogenesis. Hence,
imaging the subcellular dynamics of endolysosomes using high-resolution fluorescent …

Two-photon absorbing fluorescent probes have emerged as powerful imaging tools for
subcellular-level monitoring of biological substances and processes, offering advantages …

Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient
sensing, and autophagy. Live imaging has revealed lysosome subpopulations with …

Limited by spatial and temporal resolution, traditional optical microscopy cannot image the
delicate ultra-structure organelles and sub-organelles. The emergence of super-resolution …