Ependymal cells are indispensable components of the central nervous system (CNS). They
originate from neuroepithelial cells of the neural plate and show heterogeneity, with at least …

The belief that the vertebrate brain functions normally without classical lymphatic drainage
vessels has been held for many decades. On the contrary, new findings show that functional …

Spatial transcriptomic and proteomic technologies have provided new opportunities to
investigate cells in their native microenvironment. Here we present Giotto, a comprehensive …

Astrocytes possess different morphological characteristics depending on the cerebral region
in which they are found. However, none of the current astrocytic markers can label all …

The central nervous system's (CNS) complicated design is a double-edged sword. On the
one hand, the complexity is what gives rise to higher order thinking; but on the other hand …

The neuroepithelium is a germinal epithelium containing progenitor cells that produce
almost all of the central nervous system cells, including the ependyma. The neuroepithelium …

Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian
brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the …

Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …

Ependymal cells form a specialized brain–cerebrospinal fluid (CSF) interface and regulate
local CSF microcirculation. It is becoming increasingly recognized that ependymal cells …