Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major
depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can …

DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

In recent years, escitalopram (ESC) has been suggested to have different mechanisms of
action beyond its well known selective serotonin reuptake inhibition. The aim of this study is …

Despite the significant prevalence of Major Depressive Disorder in the pediatric population,
the pathophysiology of this condition remains unclear, and the treatment outcomes poor …

The existence of a proportional relationship between the number of early-life stress (ELS)
events experienced and the impoverishment of child mental health has been hypothesized …

Background Epigenetic changes are considered the main mechanisms behind the interplay
of environment and genetic susceptibility in major depressive disorder (MDD). However …

Background Treatment-resistant depression (TRD) results in huge healthcare costs and
poor patient clinical outcomes. Most studies have adopted a “candidate mechanism” …

Background: Alterations in DNA methylation play an important role in cancer development
and progression. Dietary nutrients and lifestyle behaviors can influence DNA methylation …

Electroconvulsive therapy (ECT) is a quick-acting and powerful antidepressant treatment
considered to be effective in treating severe and pharmacotherapy-resistant forms of …

According to the World Health Organization (WHO), major depressive disorder (MDD) is the
fourth leading cause of disability worldwide and the second most common disease after …