Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …

Regulation of cell volume is critical for many cellular and organismal functions, yet the
molecular identity of a key player, the volume-regulated anion channel VRAC, has remained …

Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …

ATP released from airway epithelial cells promotes purinergic receptor-regulated
mucociliary clearance activities necessary for innate lung defense. Cell swelling-induced …

Volume-regulated anion channels (VRACs) play an important role in controlling cell volume
by opening upon cell swelling. Recent work has shown that heteromers of LRRC8A with …

The volume-regulated anion channel (VRAC) is a ubiquitously expressed yet highly
enigmatic member of the superfamily of chloride/anion channels. It is activated by cellular …

The hypothesis that regulated ATP release from red blood cells (RBCs) contributes to nitric
oxide-dependent control of local blood flow has sparked much interest in underlying release …

In response to swelling, mammalian cells release chloride and organic osmolytes through
volume-regulated anion channels (VRACs). VRACs are heteromers of LRRC8A and other …