Decades of research have demonstrated an incontrovertible role of amyloid-β (Aβ) in the
etiology of Alzheimer's disease (AD). However, the overemphasis on the pathological …

Objective The retromer complex plays an essential role in intracellular endosomal sorting.
Deficits in the retromer complex are linked to enhanced Aβ production. The levels of the …

Objectives Due to increased gene dose for the amyloid precursor protein (APP), elderly
adults with Down syndrome (DS) are at a markedly increased risk of Alzheimer's disease …

Background Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential
role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying …

Background: There are various molecular hypotheses regarding Alzheimer's disease (AD)
like amyloid deposition, tau propagation, neuroinflammation, and synaptic dysfunction …

Recent research by Gao et al. published in Cell proposes that circulating β2-microglobulin
impairs synaptic function through antagonizing NMDA receptors in two mouse models of …

Synaptic dysfunction: Alzheimer's disease (AD) is a prevalent form of dementia, affecting
over 35 million people worldwide (Tzioras et al., 2023). A synapse serves as the connection …

Abstract Down syndrome (DS; trisomy 21) significantly impacts the human population,
affecting up to six million people, and understanding the underlying mechanisms is crucial …

Multi-omic studies ranging from genomics, transcriptomics (eg, gene expression) to
proteomics data exploration have been widely applied to interpret findings from genome …

Down syndrome (DS), caused by trisomy of chromosome 21 (Hsa21), causes the
development of Alzheimer's disease (AD), due to people with DS having three-copies of the …