Proteomic profiling and artificial intelligence for hepatocellular carcinoma translational medicine
Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver with high
morbidity and mortality rates worldwide. Since 1963, when alpha-fetoprotein (AFP) was …
morbidity and mortality rates worldwide. Since 1963, when alpha-fetoprotein (AFP) was …
Physiology of alpha-fetoprotein as a biomarker for perinatal distress: relevance to adverse pregnancy outcome
GJ Mizejewski - Experimental biology and medicine, 2007 - journals.sagepub.com
The many physiologic roles of human alpha-fetoprotein (HAFP) and its correlation with
perinatal distress/pregnancy outcome are rarely addressed together in the biomedical …
perinatal distress/pregnancy outcome are rarely addressed together in the biomedical …
Short linear motifs in colorectal cancer interactome and tumorigenesis
C Fasano, V Grossi, G Forte, C Simone - Cells, 2022 - mdpi.com
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for
cancer initiation, progression, and invasion. This multistage process is based on a dense …
cancer initiation, progression, and invasion. This multistage process is based on a dense …
Elucidating binding sites and affinities of ERα agonists and antagonists to human alpha-fetoprotein by in silico modeling and point mutagenesis
Alpha-fetoprotein (AFP) is a major embryo-and tumor-associated protein capable of binding
and transporting a variety of hydrophobic ligands, including estrogens. AFP has been shown …
and transporting a variety of hydrophobic ligands, including estrogens. AFP has been shown …
Short linear motifs orchestrate functioning of human proteins during embryonic development, redox regulation, and cancer
SS Sologova, SP Zavadskiy, IM Mokhosoev… - Metabolites, 2022 - mdpi.com
Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins that
represent amino acid stretches composed of 3 to 10 residues. The biological activities of two …
represent amino acid stretches composed of 3 to 10 residues. The biological activities of two …
Molecular analysis of AFP and HSA interactions with PTEN protein
M Zhu, B Lin, P Zhou, M Li - BioMed Research International, 2015 - Wiley Online Library
Human cytoplasmic alpha‐fetoprotein (AFP) has been classified as a member of the
albuminoid gene family. The protein sequence of AFP has significant homology to that of …
albuminoid gene family. The protein sequence of AFP has significant homology to that of …
[PDF][PDF] CURRENT CONCEPT OF THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF ALFA-FETOPROTEIN AND THE POSSIBILITIES OF ITS CLINICAL …
OK Gulevskyy, YS Akhatova - Biotechnologia Acta, 2021 - biotechnology.kiev.ua
This paper was aimed to review the literature data from native and foreign sources
accumulated for 40-years period of research of the features of the molecular structure …
accumulated for 40-years period of research of the features of the molecular structure …
Cell adhesion proteins and α-fetoprotein. Similar structural motifs as prerequisites for common functions
AA Terentiev, NT Moldogazieva - Biochemistry (Moscow), 2007 - Springer
This review summarizes and analyzes data on structural and functional relationships
between cell adhesion proteins and α-fetoprotein (AFP), which play an important role in …
between cell adhesion proteins and α-fetoprotein (AFP), which play an important role in …
[PDF][PDF] Alpha-fetoprotein and growth factors. Structure/function relationships and analogies
NT Moldogazieva, AA Terentiev - Usp. Biol. Chim, 2006 - researchgate.net
Alpha-fetoprotein (AFP) is a major embryo-specific and tumor-associated protein which is
characteristic for all mammals and, possibly, for all vertebrates. Experimental data …
characteristic for all mammals and, possibly, for all vertebrates. Experimental data …
Clinical characteristics of hepatocellular carcinoma patients with normal serum alpha‐fetoprotein level: A study of 112 consecutive cases
L Li, J Chen, W Xu, X Ding, X Wang… - Asia‐Pacific Journal of …, 2018 - Wiley Online Library
Background Serum alpha‐fetoprotein (AFP) level is normal in 30–40% of hepatocellular
carcinoma (HCC) patients, and knowledge on its characteristics and clinical outcome is …
carcinoma (HCC) patients, and knowledge on its characteristics and clinical outcome is …