Proteomic profiling and artificial intelligence for hepatocellular carcinoma translational medicine

NT Moldogazieva, IM Mokhosoev, SP Zavadskiy… - Biomedicines, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver with high
morbidity and mortality rates worldwide. Since 1963, when alpha-fetoprotein (AFP) was …

Physiology of alpha-fetoprotein as a biomarker for perinatal distress: relevance to adverse pregnancy outcome

GJ Mizejewski - Experimental biology and medicine, 2007 - journals.sagepub.com
The many physiologic roles of human alpha-fetoprotein (HAFP) and its correlation with
perinatal distress/pregnancy outcome are rarely addressed together in the biomedical …

Short linear motifs in colorectal cancer interactome and tumorigenesis

C Fasano, V Grossi, G Forte, C Simone - Cells, 2022 - mdpi.com
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for
cancer initiation, progression, and invasion. This multistage process is based on a dense …

Elucidating binding sites and affinities of ERα agonists and antagonists to human alpha-fetoprotein by in silico modeling and point mutagenesis

NT Moldogazieva, DS Ostroverkhova… - International Journal of …, 2020 - mdpi.com
Alpha-fetoprotein (AFP) is a major embryo-and tumor-associated protein capable of binding
and transporting a variety of hydrophobic ligands, including estrogens. AFP has been shown …

Short linear motifs orchestrate functioning of human proteins during embryonic development, redox regulation, and cancer

SS Sologova, SP Zavadskiy, IM Mokhosoev… - Metabolites, 2022 - mdpi.com
Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins that
represent amino acid stretches composed of 3 to 10 residues. The biological activities of two …

Molecular analysis of AFP and HSA interactions with PTEN protein

M Zhu, B Lin, P Zhou, M Li - BioMed Research International, 2015 - Wiley Online Library
Human cytoplasmic alpha‐fetoprotein (AFP) has been classified as a member of the
albuminoid gene family. The protein sequence of AFP has significant homology to that of …

[PDF][PDF] CURRENT CONCEPT OF THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF ALFA-FETOPROTEIN AND THE POSSIBILITIES OF ITS CLINICAL …

OK Gulevskyy, YS Akhatova - Biotechnologia Acta, 2021 - biotechnology.kiev.ua
This paper was aimed to review the literature data from native and foreign sources
accumulated for 40-years period of research of the features of the molecular structure …

Cell adhesion proteins and α-fetoprotein. Similar structural motifs as prerequisites for common functions

AA Terentiev, NT Moldogazieva - Biochemistry (Moscow), 2007 - Springer
This review summarizes and analyzes data on structural and functional relationships
between cell adhesion proteins and α-fetoprotein (AFP), which play an important role in …

[PDF][PDF] Alpha-fetoprotein and growth factors. Structure/function relationships and analogies

NT Moldogazieva, AA Terentiev - Usp. Biol. Chim, 2006 - researchgate.net
Alpha-fetoprotein (AFP) is a major embryo-specific and tumor-associated protein which is
characteristic for all mammals and, possibly, for all vertebrates. Experimental data …

Clinical characteristics of hepatocellular carcinoma patients with normal serum alpha‐fetoprotein level: A study of 112 consecutive cases

L Li, J Chen, W Xu, X Ding, X Wang… - Asia‐Pacific Journal of …, 2018 - Wiley Online Library
Background Serum alpha‐fetoprotein (AFP) level is normal in 30–40% of hepatocellular
carcinoma (HCC) patients, and knowledge on its characteristics and clinical outcome is …