In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …

Immunotherapy, specifically immune checkpoint inhibitors, is revolutionizing cancer
treatment, achieving durable control of previously incurable or advanced tumors. However …

While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …

Allergic diseases are immune system dysfunctions mediated by mast cell (MC) activation
stimulated by specific allergens. However, current small molecular MC stabilizers for allergic …

While most nanomedicines primarily aim to stimulate the immune system against infections
or tumors, there is a growing demand for inducing immune tolerance under certain …

Liver-targeting nanoparticles have emerged as a promising platform for the induction of
immune tolerance by taking advantage of the liver's unique tolerogenic properties and …

Autoimmune diseases, allergies, transplant rejections, generation of antidrug antibodies,
and chronic inflammatory diseases have impacted a large group of people across the globe …

Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger a
wide range of symptoms from mild to life-threatening. This adverse reaction is caused by …

Liver transplantation (LT) is used in clinics for treatment of hepatocellular carcinoma (HCC)
but it faces a paradox, ie, immunosuppression is needed to prevent LT rejection, but it can …

Impairment of immune tolerance might cause autologous tissue damage or overactive
immune response against non-pathogenic molecules. Although autoimmune disease and …