The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …

Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of
Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein …

The last 15 years saw a dramatic increase in the number of published papers exposing
research related to the concept of protein disorder and a concomitant increase in the …

Parkinson's disease, originating from the intrinsically disordered peptide α-synuclein, is a
common neurodegenerative disorder that affects more than 5% of the population above age …

Aggregates of α-synuclein are thought to be the disease-causing agent in Parkinson's
disease. Various case studies have hinted at a correlation between COVID-19 and the onset …

Proteins that exhibit intrinsically disordered regions (IDRs) are prevalent in the human
proteome and perform diverse biological functions, including signaling and regulation. Due …

Intrinsically disordered proteins (IDPs) are broadly defined as protein regions that do not
cooperatively fold into a spatially or temporally stable structure. Recent research strongly …

Thioflavin T (ThT) is widely employed as a fluorogenic marker for amyloid formation. ThT
fluorescence is utilized to detect amyloid fibrils as well as to follow aggregation kinetics …

Characterization of the amyloidogenic Parkinson's disease protein α-synuclein (αS) has
proven difficult due to its structural plasticity. Here, we present a number of complementary …

Single molecule fluorescence spectroscopy is emerging as an extremely powerful and
sensitive tool to study complex biological problems. Single molecule fluorescence …