MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …

Gliomas are the most common primary brain tumor and are uniformly lethal. Despite
significant advancements in understanding the genetic landscape of gliomas, standard-of …

Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers.
However, we lack experimental models for validating their tumorigenic impact. Here, we …

Preoperative MRI is an essential diagnostic and therapeutic reference for gliomas. This
study aims to evaluate the prognostic aspect of a radiomics biomarker for glioma and further …

Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-
growing but inevitably progress to fatal disease. To characterize their malignant cell …

Clonal evolution drives cancer progression and therapeutic resistance. Recent studies have
revealed divergent longitudinal trajectories in gliomas, but early molecular features steering …

Gliomas are primary brain tumours that are thought to develop from neural stem or
progenitor cells that carry tumour-initiating genetic alterations. Based on microscopic …

Gliomas are primary brain tumours that are thought to develop from neural stem or
progenitor cells that carry tumour-initiating genetic alterations. Based on microscopic …

Previous studies on genetic diseases predominantly focused on protein-coding variations,
overlooking the vast noncoding regions in the human genome. The development of high …

Background Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer with a
high incidence in Southern China and Southeast Asia. Patients with remote metastasis and …