Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's disease: a systematic review

WA Rike, S Stern - International Journal of Molecular Sciences, 2023 - mdpi.com
The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …

Brain‐targeted liposomes loaded with monoclonal antibodies reduce alpha‐synuclein aggregation and improve behavioral symptoms in Parkinson's disease

M Sela, M Poley, P Mora‐Raimundo… - Advanced …, 2023 - Wiley Online Library
Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

JA Ortega, GP Soares de Aguiar… - Wiley …, 2024 - Wiley Online Library
The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …

Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson's disease patients

I Rosh, U Tripathi, Y Hussein, WA Rike… - npj Parkinson's …, 2024 - nature.com
Parkinson's disease (PD) is a neurodegenerative disease with both genetic and sporadic
origins. In this study, we investigated the electrophysiological properties, synaptic activity …

Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations

Y Hussein, U Tripathi, A Choudhary, R Nayak… - Translational …, 2023 - nature.com
Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …

Dopaminergic system and neurons: role in multiple neurological diseases

H Chen, J Li, Z Huang, X Fan, X Wang, X Chen… - …, 2024 - Elsevier
The dopaminergic system is a complex and powerful neurotransmitter system in the brain. It
plays an important regulatory role in motivation, reward, cognition, and motor control. In …

A systematic review of extracellular matrix-related alterations in Parkinson's disease

MA Chapman, BA Sorg - Brain Sciences, 2024 - mdpi.com
The role of the extracellular matrix (ECM) in Parkinson's disease (PD) is not well understood,
even though it is critical for neuronal structure and signaling. This systematic review …

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

AJ White, KA Clark, KD Alexander… - npj Parkinson's …, 2024 - nature.com
Abstract Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate
with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies …

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

S Stern, L Zhang, M Wang, R Wright, I Rosh… - Molecular …, 2024 - nature.com
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and
environmental factors are known to play a role in this psychiatric disorder. While there is a …

[HTML][HTML] Parkinson's disease risk enhancers in microglia

A Booms, SE Pierce, EJC van der Schans, GA Coetzee - Iscience, 2024 - cell.com
Genome-wide association studies have identified thousands of single nucleotide
polymorphisms that associate with increased risk for Parkinson's disease (PD), but the …