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Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's disease: a systematic review
The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …
Brain‐targeted liposomes loaded with monoclonal antibodies reduce alpha‐synuclein aggregation and improve behavioral symptoms in Parkinson's disease
Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …
poor delivery to the brain hinders their therapeutic application. In the current study, it is …
Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies
JA Ortega, GP Soares de Aguiar… - Wiley …, 2024 - Wiley Online Library
The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …
Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson's disease patients
Parkinson's disease (PD) is a neurodegenerative disease with both genetic and sporadic
origins. In this study, we investigated the electrophysiological properties, synaptic activity …
origins. In this study, we investigated the electrophysiological properties, synaptic activity …
Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations
Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …
Dopaminergic system and neurons: role in multiple neurological diseases
H Chen, J Li, Z Huang, X Fan, X Wang, X Chen… - …, 2024 - Elsevier
The dopaminergic system is a complex and powerful neurotransmitter system in the brain. It
plays an important regulatory role in motivation, reward, cognition, and motor control. In …
plays an important regulatory role in motivation, reward, cognition, and motor control. In …
A systematic review of extracellular matrix-related alterations in Parkinson's disease
MA Chapman, BA Sorg - Brain Sciences, 2024 - mdpi.com
The role of the extracellular matrix (ECM) in Parkinson's disease (PD) is not well understood,
even though it is critical for neuronal structure and signaling. This systematic review …
even though it is critical for neuronal structure and signaling. This systematic review …
A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons
AJ White, KA Clark, KD Alexander… - npj Parkinson's …, 2024 - nature.com
Abstract Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate
with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies …
with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies …
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and
environmental factors are known to play a role in this psychiatric disorder. While there is a …
environmental factors are known to play a role in this psychiatric disorder. While there is a …
[HTML][HTML] Parkinson's disease risk enhancers in microglia
A Booms, SE Pierce, EJC van der Schans, GA Coetzee - Iscience, 2024 - cell.com
Genome-wide association studies have identified thousands of single nucleotide
polymorphisms that associate with increased risk for Parkinson's disease (PD), but the …
polymorphisms that associate with increased risk for Parkinson's disease (PD), but the …