The microbiota is composed of commensal bacteria and other microorganisms that live on
the epithelial barriers of the host. The commensal microbiota is important for the health and …

Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide
range of pediatric and adult malignances. However, it has various side effects which limit its …

Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies.
However, its primary dose‐limiting side effect is kidney injury, which is a major clinical …

Purpose Reactive oxygen species (ROS) are produced in cancer cells as a result of
increased metabolic rate, dysfunction of mitochondria, elevated cell signaling, expression of …

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys,
which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a …

Commensal microorganisms (the microbiota) live on all the surface barriers of our body and
are particularly abundant and diverse in the distal gut. The microbiota and its larger host …

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …

Fatty acid oxidation (FAO) dysfunction is one of the important mechanisms of renal fibrosis.
Sirtuin 3 (Sirt3) has been confirmed to alleviate acute kidney injury (AKI) by improving …

Acute kidney injury (AKI) is a major kidney disease featured by a rapid decline of renal
function. Pathologically, AKI is characterized by tubular epithelial cell injury and death …