Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

Platelets are anuclear cells with a short lifespan that play an essential role in many
pathophysiological processes, including haemostasis, inflammation, infection, vascular …

Inherited platelet disorders are a heterogeneous group of rare diseases, caused by inherited
defects in platelet production and/or function. Their genetic diagnosis would benefit clinical …

Abstract β1-Tubulin plays a major role in proplatelet formation and platelet shape
maintenance, and pathogenic variants in TUBB1 lead to thrombocytopenia and platelet …

Understanding the underlying mechanisms of the well-substantiated platelet hyporeactivity
in neonates is of interest given their implications for the clinical management of newborns, a …

The GATA1 transcription factor is essential for normal erythropoiesis and megakaryocytic
differentiation. Germline GATA1 pathogenic variants in the N-terminal zinc finger (N-ZF) are …

Neonatal platelets are hyporeactive and show impaired agonist-induced secretion despite
no obvious abnormalities in their granules. Here, we examined, for the first time, the …

Platelet function in primary hemostasis involves the secretion of granules upon activation,
providing the localized delivery of effector proteins at sites of vascular injury. The sequential …

Predictive biomarkers are needed in immune thrombocytopenia (ITP). Single nucleotide
polymorphisms (SNP s) in beta 1 tubulin are potential candidates, as beta 1 tubulin is …

Background An asymptomatic macrothrombocytopenia, phenotypically similar to
asymptomatic inherited macrothrombocytopenia in Cavalier King Charles Spaniels, was …