Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-
derived nucleic acids and respond with rapid and massive production of type I interferon …

Microbial infections are recognized by the innate immune system both to elicit immediate
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the
production of type I interferons (IFNs). pDCs promote antiviral immune responses and have …

Classical dendritic cells (cDCs) form a critical interface between innate and adaptive
immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of …

Adaptive cellular immunity is initiated by antigen-specific interactions between T
lymphocytes and dendritic cells (DCs). Plasmacytoid DCs (pDCs) support antiviral immunity …

Dendritic cells (DC) are key regulators of both protective immune responses and tolerance
to self‐antigens. Soon after their discovery in lymphoid tissues by Steinman and Cohn, as …

The innate immune system in drosophila and mammals senses the invasion of
microorganisms using the family of Toll receptors, stimulation of which initiates a range of …

Peripheral blood monocytes are a heterogeneous population of circulating leukocytes.
Using a murine adoptive transfer system to probe monocyte homing and differentiation in …

Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus
recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce …

Recognition of microbial infection and initiation of host defense responses is controlled by
multiple mechanisms. Toll-like receptors (TLRs) have recently emerged as a key component …