Antibody‐drug conjugates (ADCs) have emerged as a promising class of biologics since the
first approval of Gemtuzumab ozogamicin in 2000. Compared to small molecule drugs …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

Lipid nanoparticle (LNP)–mRNA complexes are transforming medicine. However, the
medical applications of LNPs are limited by their low endosomal disruption rates, high …

Event-driven bifunctional molecules, typified by proteolysis targeting chimera (PROTAC)
technology, have been successfully applied in degrading many proteins of interest (POI) …

Photolysis‐based prodrug strategy can address some critical drug delivery issues, which
otherwise are very challenging to tackle with traditional prodrug strategy. However, the need …

Oral protein drug delivery using nano-based systems remains challenging, as contradictory
surface properties are required for efficient navigation through the intestinal mucus and …

Hydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the targeted
delivery and real‐time feedback of exogenous H2S are still challenging. With the aid of …

Bone-related diseases refer to a group of skeletal disorders that are characterized by bone
and cartilage destruction. Conventional approaches can regulate bone homeostasis to a …

Bioconjugation deals with the chemical modification of proteins. The reactions used exploit
either the intrinsic chemical reactivity of the biomolecule or introduce functionalities that can …

Structures of the large majority of bioactive molecules are composed of several rings that are
decorated by substituents and connected by linkers. While numerous cheminformatics …