Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a
common signaling pathway used to transduce signals from the extracellular to the …

Gastric cancer (GC) is among the most common malignancy in the world with poor
prognosis and limited treatment options. It has been established that gastric carcinogenesis …

Combination immunotherapy is promising to overcome the limited objective response rates
of immune checkpoint blockade (ICB) therapy. Here, a tumor immunological phenotype (TIP) …

The Aurora A inhibitor alisertib shows encouraging activities in clinical trials against
advanced breast cancer. However, it remains unclear whether and how the inflammatory …

Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two
decades, several studies have shown amplification and overexpression of Aurora kinase A …

Aurora kinase A (AURKA) regulates apoptosis and autophagy in various diseases and has
shown promising clinical effects. Nevertheless, the complex regulatory mechanism of …

Background Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-
specific pathways have shown immense promise in preclinical and clinical studies aimed at …

Ovarian carcinoma is the fifth leading cause of death among women in the United States.
Persistent activation of STAT3 is frequently detected in ovarian carcinoma. STAT3 is …

Background/Aims: Kinesin family member 20A (KIF20A) is upregulated in multiple cancers
and plays important roles in promoting malignant behavior, whereas its exact role in CRC …

Abstract Background Aurora kinase A (AURKA) has been implicated in the regulation of cell
cycle progression, mitosis and a key number of oncogenic signaling pathways in various …