The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular
processes and are potential therapeutic targets owing to their involvement in diseases such …

Ubiquitination is a post-translational modification (PTM) that is essential for balancing
numerous physiological processes. To enable delineation of protein ubiquitination at a site …

Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Chaperone-mediated autophagy (CMA) contributes to the lysosomal degradation of a
selective subset of proteins. Selectivity lies in the chaperone heat shock cognate 71 kDa …

Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …

Small ubiquitin-like modifiers (SUMOs) are post-translational modifications that play crucial
roles in most cellular processes. While methods exist to study exogenous SUMOylation …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

Beside gene expression and translational control, which are relatively slow, PTM of proteins
represents the major level of regulation, from very fast and reversible to slow or irreversible …