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Revisiting the potential of natural products in antimycobacterial therapy: advances in drug discovery and semisynthetic solutions
M George, GD Wright - Current Opinion in Microbiology, 2025 - Elsevier
Natural products have been pivotal in treating mycobacterial infections with early antibiotics
such as streptomycin, forming the foundation of tuberculosis therapy. However, the …
such as streptomycin, forming the foundation of tuberculosis therapy. However, the …
Multifactorial genetic control and magnesium levels govern the production of a Streptomyces antibiotic with unusual cell density dependence
Streptomyces bacteria are renowned both for their antibiotic production capabilities and for
their cryptic metabolic potential. Their metabolic repertoire is subject to stringent genetic …
their cryptic metabolic potential. Their metabolic repertoire is subject to stringent genetic …
[HTML][HTML] Application of the Rumsfeld matrix to anticancer natural product target discovery
C Bailly - Pharmacological Research-Reports, 2024 - Elsevier
For a long time, natural products (NP) contribute to the treatment of human pathologies,
notably to cancer treatment with microbial and plant-derived products. The mechanism of …
notably to cancer treatment with microbial and plant-derived products. The mechanism of …
Antimicrobial and antibiofilm activity of specialized metabolites isolated from Centaurea hyalolepis
The discovery of plant-derived compounds that are able to combat antibiotic-resistant
pathogens is an urgent demand. Over years, Centaurea hyalolepis attracted considerable …
pathogens is an urgent demand. Over years, Centaurea hyalolepis attracted considerable …
[HTML][HTML] A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial Ribosome
Lasso peptides, biologically active molecules with a distinct structurally constrained knotted
fold, are natural products belonging to the class of ribosomally-synthesized and …
fold, are natural products belonging to the class of ribosomally-synthesized and …
Butyrolactol A is a phospholipid flippase inhibitor that potentiates the bioactivity of caspofungin against resistant fungi
X Chen, HD Duan, MJ Hoy, K Koteva, M Spitzer… - bioRxiv, 2025 - biorxiv.org
Fungal infections cause millions of deaths annually and are challenging to treat due to
limited antifungal options and increasing drug resistance. Cryptococci are intrinsically …
limited antifungal options and increasing drug resistance. Cryptococci are intrinsically …
A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris
The rise of drug-resistant fungal pathogens, including Candida auris, highlights the urgent
need for novel antifungal therapies. We developed a cost-effective platform combining …
need for novel antifungal therapies. We developed a cost-effective platform combining …
Using Biofilms to Identify Novel Antibiotics and Assess Infection Prevention Methods
V Coles - 2024 - macsphere.mcmaster.ca
As antimicrobial resistance proliferates, standard treatments for bacterial infections are
rendered ineffective. There is therefore a need to both prevent infections and develop new …
rendered ineffective. There is therefore a need to both prevent infections and develop new …
[DOC][DOC] A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris
The rise of drug-resistant fungal pathogens, including Candida auris, highlights the urgent
need for novel antifungal therapies. We developed a cost-effective platform combining …
need for novel antifungal therapies. We developed a cost-effective platform combining …